Spider-Man arrived in 1962 as a radioactive bite. That premise has never been scientifically coherent—nor did it need to be.
Origin stories operate in mythology space, not biology. The story works when it sounds like it could work and anchors wonder in something that feels technical enough to believe.
A radioactive spider wouldn't develop super-powers; the radiation would damage its own cellular machinery, making it sick or dead. If it somehow survived long enough to bite you, the dose you'd receive would be trivial—acute radiation poisoning in humans requires exposure measured in grays. A single contaminated arthropod bite delivers virtually nothing.
Your body wouldn't recognize it as a threat, so there would be no mutation cascade, no web-shooting proteins, no wall-crawling reflex. No Spider-Man. We've been trained by 60 years of superhero narrative to believe that radiation causes enhancement—but it doesn't. Radiation causes damage; it damages DNA in ways that produce scar tissue, not superpowers.
The complaint was never really about whether radioactivity works that way—it was about whether the franchise itself still works at all.
Somewhere in the middle of the larger conversation about superhero saturation, someone mistook scientific debunking for cultural criticism. When you care deeply about a franchise, you eventually need reasons that feel more substantial than "I'm bored," so you reach for science and say the premise doesn't hold up biologically—because that sounds rigorous and like you've thought it through.